Triethylamine → HCID 54270909, compound

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Reaction Steps

Next, 20.3 g of piperidine-4-carboxylic acid t-butyl ester is dissolved in 100 ml of CH2Cl2 and cooled in an ice bath. Under a nitrogen atmosphere, 12 ml of triethylamine and then, 8.2 ml of acryloyl chloride solution in CH2Cl2 are added dropwise to the ester solution. This mixture is completely mixed by stirring for 5 hrs. Thereafter, this mixture is washed three times with 20 ml of 1 N HCl, washed another three times with 20 ml of NaHCO3 and then washed once with 25 ml of brine water, and dried over MgSO4 to obtain N-acryloyl-piperidine-4-carboxylic acid t-butyl ester.

Provenance & Evidence