HuagongsheHuagongshe Chemistry Print Report · For research reference only
o-Chlorophenylacetic acid → Acetyl chloride, 2-(2-chlorophenyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | o-Chlorophenylacetic acid | HCID 17124 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Acetyl chloride, 2-(2-chlorophenyl)- | HCID 182669 | — |
Reaction Steps
Oxalyl chloride (38 ml) and a few drops of N,N-dimethylformamide was added to a solution of (2-chlorophenyl)acetic acid (50 g) in CH2Cl2 (300 ml). The mixture was stirred at room temperature for 3 hours, and then concentrated under reduced pressure. The residue was distilled under reduced pressure to give (2-chlorophenyl)acetyl chloride (41.24 g) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05888972 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-deb98a2af6c84caa9968da632cdc7d1e |
| Source note | uspto-grants-1999_03 |