HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diphosgene → 4-Chloro-6-fluoro-7-isocyanato-2-methylbenzothiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diphosgene | HCID 10426 | — |
| Reactant | 7-Amino-4-chloro-6-fluoro-2-methylbenzothiazole | HCID 53709923 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-Chloro-6-fluoro-7-isocyanato-2-methylbenzothiazole | HCID 54438417 | — |
Reaction Steps
A solution of 3.2 g (15 mmol) of 7-amino-4-chloro-6-fluoro-2-methylbenzothiazole and 15 g (76 mmol) of diphosgene in 150 ml of toluene was refluxed for 6 hours. The crude product obtained after evaporation was converted directly into active ingredient I.15.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05888940 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-5d3c618f49644c5b8a16839dda23b30d |
| Source note | uspto-grants-1999_03 |