Phosgene → HCID 178473406, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of N-(4-ethoxycarbonylamino-1-methyl-5-pyrazolesulfonyl)-N'-isopropylthiourea (0.37 g) and triethylamine (0.45 ml) in 5 ml of dry THF at 0° C. was added 1.0 ml of a 20% solution of phosgene in toluene. The mixture was stirred at 0° C. for 30 min. and then evaporated to dryness. The residue was triturated with 10 ml of water, filtered off, rinsed on the filter with water and dried to give 0.27 g (82%) of the title compound; m.p. 141°-145° C.

Provenance & Evidence