HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2-(4-Aminocyclohexyl)-1,1,1-trifluoro-2-propanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-(2-Hydroxy-1,1,1-trifluoro-2-propyl)cyclohexanone | HCID 14412981 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Rhodium | HCID 23948 | — |
| Product | 2-(4-Aminocyclohexyl)-1,1,1-trifluoro-2-propanol | HCID 54449113 | — |
Reaction Steps
11.1 g (53 mmol) of 4-(2-hydroxy-1,1,1-trifluoro-2-propyl)cyclohexanone were subjected to reductive amination in 150 ml of ammonia-saturated methanol in the presence of 2.3 g of rhodium (5% on charcoal) with 50 bar of hydrogen. 9.0 g (80.1% of theory) were obtained of a colorless oil which was reacted without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05889012 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-e16c9027f930453fbe83965133e99e15 |
| Source note | uspto-grants-1999_03 |