HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(1,1,1-Trifluoro-2-hydroxypropan-2-yl)phenol → 4-(2-Hydroxy-1,1,1-trifluoro-2-propyl)cyclohexanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(1,1,1-Trifluoro-2-hydroxypropan-2-yl)phenol | HCID 54439946 | — |
| Catalyst | Rhodium | HCID 23948 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 4-(2-Hydroxy-1,1,1-trifluoro-2-propyl)cyclohexanol | HCID 53908967 | — |
Reaction Steps
18.9 g (0.092 mol) of 4-(2-hydroxy-1,1,1-trifluoro-2-propyl)phenol were hydrogenated in a mixture of 200 ml of isopropanol and 6 ml of concentrated hydrochloric acid in the presence of 2.3 g of rhodium (5% on charcoal) at 150 bar and 50° C. After filtration to remove the catalyst and concentration, 18.8 g (96.6% of theory) remained of a colorless product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05889012 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-d0d4752887c24f14bb1f64ec4d666a79 |
| Source note | uspto-grants-1999_03 |