HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → 4-(2-Hydroxy-1,1,1-trifluoro-2-propyl)phenol benzyl ether
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 1-(4-(Benzyloxy)phenyl)-2,2,2-trifluoroethanone | HCID 21252691 | — |
| Reactant | HCID 178418332 | HCID 178418332 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 4-(2-Hydroxy-1,1,1-trifluoro-2-propyl)phenol benzyl ether | HCID 57017446 | — |
Reaction Steps
A solution of 30.0 g (0.107 mol) of 4-(trifluoroacetyl)phenyl benzyl ether in 50 ml of diethyl ether was added dropwise at 0° C. to a solution of 12.0 g (0.161 mol) of methylmagnesium chloride in 150 ml of diethyl ether. After 2 hours at reflux, the mixture was poured into saturated ammonium chloride solution. 31.3 g (99% of theory) were obtained of colorless product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05889012 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-b3416da64c9c46e1bc298b70a16b7d56 |
| Source note | uspto-grants-1999_03 |