Triethylamine → HCID 178494686, compound

Participants

Reaction Steps

2.83 g (15 mmol) of 4-chloro-5-methoxy-6-methoxymethylpyrimidine [Collection Czechoslov. Chem. Commun. 33 (1968) 2266], 2.93 g (15 mmol) of cis-4-(1-methylcyclohexyl)cyclohexylamine and 3.03 g (30 mmol) of triethylamine are heated under reflux in 10 ml of toluene for 6 hours. After cooling, the mixture was subjected to extraction by stirring with water, and the organic phase was dried and concentrated. For purification it was chromatographed on silica gel (eluent: ethyl acetate). 1.2 g (23% of theory) of pure cis isomer were obtained as a colorless oil.

Provenance & Evidence