Triethylsilane → HCID 178437733, compound

Participants

Reaction Steps

2.0 g (7.3 mmol) of 5-chloro-4-(cis-4-ethenylcyclohexylamino)-6-ethylpyrimidine (Example 12) and 1.22 g (10.5 mmol) of triethylsilane were heated under reflux with a spatula tip of hexachloroplatinic acid. After hydrolysis with dilute NH4Cl solution, the mixture was subjected to extraction with ether and purified by column chromatography (silica gel, eluent system petroleum ether/ethyl acetate 9:1). 0.72 g (1.9 mmol=25%) was obtained of the silane (colorless oil, nD23 =1.5206).

Provenance & Evidence