HCID 131721210, compound → HCID 15408203, compound

HRID 1419816Notes

Reaction equation

HRID 1419816 reaction equation
[CH3:1][C:2]1[NH:3][C:4](=[O:25])[N:5]([C:21]([O:23][CH3:24])=[O:22])[CH:6]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-])=O)[CH:13]=2)[C:7]=1[C:8]([O:10][CH3:11])=[O:9]>CC(O)=O>[NH2:18][C:14]1[CH:13]=[C:12]([CH:6]2[N:5]([C:21]([O:23][CH3:24])=[O:22])[C:4](=[O:25])[NH:3][C:2]([CH3:1])=[C:7]2[C:8]([O:10][CH3:11])=[O:9])[CH:17]=[CH:16][CH:15]=1

Participants

3

Reactant 1

HCID 131721210HCID 131721210, compound

Product 1

HCID 15408203HCID 15408203, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The title compound was prepared from the compound of Example 7 according to the method described in Example 2 using AcOH as solvent. A white solid was obtained (97% yield): mp 190°-193° C.; 1H NMR (CDCl3) δ 7.65 (s, 1 H), 7.05 (t, 1 H, J=7.8 Hz), 6.69 (d, 1 H, J=7.8 Hz), 6.64 (s, 1 H), 6.57 (d, 1 H, J=7.8 Hz), 6.30 (s, 1 H), 3.86 (s, 3 H), 3.74 (s, 3 H), 2.36 (s, 3 H); 13C NMR (CDCl3) δ 165.6, 153.7, 150.1, 146.6, 145.7, 140.6, 129.6, 116.6, 114.9, 113.0, 105.0, 56.0, 54.3, 51.6, 18.1.

Workup

  1. customA white solid was obtained (97% yield)

Sources & evidence

ORD record
ord-6b4c4b5906f9401692bb4243df2a361e
Source dataset
uspto-grants-1999_03
Patent number
US05889016

Reaction notes

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