HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2-Dimethylaminoethoxy)-4-nitroanisole → 3-(2-(Dimethylamino)ethoxy)-4-methoxyaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(2-Dimethylaminoethoxy)-4-nitroanisole | HCID 10776424 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(2-(Dimethylamino)ethoxy)-4-methoxyaniline | HCID 10560398 | 100% |
Reaction Steps
A solution of 2-(2-dimethylaminoethoxy)-4-nitroanisole (D13, 11.8 g, 0.049 mole) in ethanol (200 ml) was hydrogenated over 10% Pd-C (1 g) at atmospheric temperature and pressure. The catalyst was filtered off through kieselguhr and the filtrate concentrated in vacuo to afford the title compound as a beige solid (10.3 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05889022 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-6d100e854ec349d3a004ea2ac4d23cef |
| Source note | uspto-grants-1999_03 |