Glycerol → HCID 53932050, compound

Participants

Reaction Conditions

Reaction Steps

3-(2-Dimethylaminoethoxy)-4-methoxyaniline (D14, 200 mg) was treated with glycerol (133 mg) and iodine (5 mg) and to this stirring mixture was added dropwise, concentrated sulphuric acid (267 mg). After the initial exothermic reaction had subsided, the mixture was heated at 180° C. for 1.5 hr. The reaction mixture was cooled and partitioned between 40% aqueous sodium hydroxide and ethyl acetate, the organic phase was dried (Na2SO4) and the solvent evaporated under reduced pressure to leave the title compound as a brown oil (19 mg, 51%).

Provenance & Evidence