HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 1-[(2,6-Dichloropyridin-4-yl)carbonyl]-4-methylpiperazine, hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 1-Methylpiperazine | HCID 53167 | — |
| Reactant | 2,6-Dichloro-isonicotinoyl chloride | HCID 2781643 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 1-[(2,6-Dichloropyridin-4-yl)carbonyl]-4-methylpiperazine, hydrochloride | HCID 131720335 | — |
Reaction Steps
To methylene chloride (15 mL) was added 2,6-dichloropyridine-4-carbonyl chloride (1.0 g, 4.8 mmol) and 1-methylpiperazine (0.48 g, 4.8 mmol). After stirring for 1 day, the reaction was poured into ether. The resulting solid was filtered to give 1-[(2,6-dichloropyridin-4-yl)carbonyl]-4-methylpiperazine, hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05889005 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-dd41bda6c27e4852987a50c4aa4f5299 |
| Source note | uspto-grants-1999_03 |