Water → HCID 54209053, compound

Participants

Reaction Steps

3-butyryl-4-(2,4-dimethylphenylamino)-8-(2-methylthioethoxy)quinoline (0.34g, 0.83 mmol) was dissolved in methylene chloride (4 ml). Water (2 ml) and sodium hypochlorite (5% in water) (1.39 ml) were added and the mixture was stirred for 2 h. Another portion of sodium hypochlorite (0.5 ml) was added and the stirring was continued for 2 h. The organic layer was dried over sodium sulfate and evaporated. Trituration with isopropyl ether gave 0.32 g (91%) of the title compound.

Provenance & Evidence