Hydrochloric Acid → HCID 70046883, compound

Participants

Reaction Steps

4-Benzyl-1-[3-(4-benzyloxy-phenoxy)-propyl]-piperidin-4-ol (0.432 g, 1 mmol) was dissolved in MeOH (50 ml) and hydrogenated in the presence of Pd on C at room temperature and atmospheric pressure. After filtration and evaporation of the solvent, the residue was dissolved in tetrahydrofuran (THF) (3 ml) and ether (10 ml). 1.1 equivalent of etheric HCl were added to give 4-benzyl-1-[3-(4-hydroxy-phenoxy)-propyl]-piperidin-4-ol hydrochloride (0.30 g, 88%) as colorless solid, m.p. 64° C. and MS: m/e=342.3 (M+H+).

Provenance & Evidence