HCID 70045573, compound → HCID 70048187, compound

Participants

Reaction Steps

Palladium on carbon (10%, 150 mg) was added to a solution of 4-benzyloxy-N-[2-(4-hydroxy-4-phenyl-piperidin-1-yl)-ethyl]-benzamide (500 mg, 1.12 mmol) in acetic acid (20 ml). The hydrogenation was complete after 3 h. The catalyst was removed by filtration through celite and the solvent was evaporated. Addition of sodium bicarbonate (10% aq. solution, 2 ml) and extraction with dichloromethane afforded N-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-4-hydroxy-benzamide (399 mg, 95%) as a light yellow solid.

Provenance & Evidence