HCID 70045694, compound → HCID 70047761, compound

Participants

Reaction Steps

Palladium on carbon (10%, 50 mg) was added to a solution of 4-benzyloxy-N-[3-[4-hydroxy-4-(4-methyl-benzyl)-piperidin-1-yl]-propyl]-benzamide (220 mg, 0.46 mmol) in acetic acid (5 ml). The hydrogenation was complete after 4 h. The catalyst was removed by filtration through celite and the solvent was evaporated. Sodium bicarbonate (10% aq. solution, 2 ml) was added, and the aqeous layer extracted with dichloromethane. The organic layer was dried (Na2SO4), filtered and evaporated to give 4-hydroxy-N-[3-[4-hydroxy-4-(4-methyl-benzyl)-piperidin-1-yl]-propyl]-benzamide (178 mg,73%) as a white solid. MS: me/e=383 (M+H)+.

Provenance & Evidence