HCID 70045808, compound → HCID 70048708, compound

Participants

Reaction Steps

Palladium on carbon (10%, 60 mg) was added to a solution of 4-benzyloxy-N-[2-[4-hydroxy-4-(4-methyl-benzyl)-piperidin-1-yl]-ethyl]-N-methyl-benzamide (226 mg, 0.48 mmol) in acetic acid (6 ml). The hydrogenation was complete after 4 h. The catalyst was removed by filtration through celite and the solvent was evaporated. Sodium bicarbonate (10% aq. solution, 2 ml) was added, and the aqeous layer extracted with dichloromethane. The organic layer was dried (Na2SO4), filtered and to give 4-hydroxy-N-[2-[4-hydroxy-4-(4-methyl-benzyl)-piperidin-1-yl]-ethyl ]-N-methyl-benzamide (135 mg, 74%) as a white solid. MS: me/e=383 (M+H)+.

Provenance & Evidence