4-(4-Methylbenzyl)-piperidin-4-ol → 1-[3-(2-Benzyloxy-phenoxy)-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol

HRID 1419918Notes

Reaction equation

HRID 1419918 reaction equation
Br[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[CH3:20][C:21]1[CH:34]=[CH:33][C:24]([CH2:25][C:26]2([OH:32])[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[CH:23][CH:22]=1>>[CH2:13]([O:12][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=1[O:5][CH2:4][CH2:3][CH2:2][N:29]1[CH2:30][CH2:31][C:26]([CH2:25][C:24]2[CH:23]=[CH:22][C:21]([CH3:20])=[CH:34][CH:33]=2)([OH:32])[CH2:27][CH2:28]1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 105362424-(4-Methylbenzyl)-piperidin-4-olHCID 53690636HCID 53690636, compound

Product 1

HCID 700462251-[3-(2-Benzyloxy-phenoxy)-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol

Procedure

The title compound, MS: m/e=446.5(M+H+), was prepared from 1-(3-bromopropoxy)-2-(benzyloxy)-benzene and 4-(4-methyl-benzyl)-piperidin-4-ol.

Sources & evidence

ORD record
ord-1505cf6d13ef4385bd11ca1411755ba5
Source dataset
uspto-grants-1999_03
Patent number
US05889026

Reaction notes

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