1-(Benzyloxy)-4-(2-bromoethoxy)benzene → 1-[2-(4-Benzyloxy-phenoxy)-ethyl]-4-(4-methoxy-benzyl)-piperidin-4-ol

HRID 1419919Notes

Reaction equation

HRID 1419919 reaction equation
Br[CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:7][CH:6]=1.[CH3:19][O:20][C:21]1[CH:34]=[CH:33][C:24]([CH2:25][C:26]2([OH:32])[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[CH:23][CH:22]=1>>[CH2:12]([O:11][C:8]1[CH:9]=[CH:10][C:5]([O:4][CH2:3][CH2:2][N:29]2[CH2:28][CH2:27][C:26]([CH2:25][C:24]3[CH:23]=[CH:22][C:21]([O:20][CH3:19])=[CH:34][CH:33]=3)([OH:32])[CH2:31][CH2:30]2)=[CH:6][CH:7]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 107570881-(Benzyloxy)-4-(2-bromoethoxy)benzeneHCID 226283494-[(4-Methoxyphenyl)methyl]piperidin-4-ol

Product 1

HCID 700483221-[2-(4-Benzyloxy-phenoxy)-ethyl]-4-(4-methoxy-benzyl)-piperidin-4-ol

Procedure

The title compound, MS: m/e=448.5 (M+H+), was prepared from 1-(2-bromoethoxy)-4-(benzyloxy)-benzene and 4-(4-methoxy-benzyl)-piperidin-4-ol.

Sources & evidence

ORD record
ord-ca13b26dc1f34cc29effb0ba69d47582
Source dataset
uspto-grants-1999_03
Patent number
US05889026

Reaction notes

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