HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1419936Generated: November 1, 2026
Ethanolamine → Benzamide, N-(2-hydroxyethyl)-4-(phenylmethoxy)-
https://huagongshe.com/reaction/1419936
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | 4-(Benzyloxy)benzoic acid | HCID 73880 | — |
| Reactant | Bis-(1H-imidazol-2-YL)-methanone | HCID 5250894 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Benzamide, N-(2-hydroxyethyl)-4-(phenylmethoxy)- | HCID 10825986 | 94.6% |
Reaction Steps
A solution of 4-benzyloxy benzoic acid (20 g, 87.6 mmol), 1,1,-carbonyl-diimidazole (14.9 g, 91.8 mmol) and DMF (80 ml) was stirred at 50° C. for 1 h. The solution is cooled to 0° C., and ethanolamine (25% in water, 81.2 g) is added. After 45 min., the precipitate was filtered to give 4-benzyloxy-N-(2-hydroxy-ethyl)-benzamide (22.49 g, 94.5%) as a white solid. MS: me/e=271 (M)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05889026 |
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| Source dataset | uspto-grants-1999_03 |
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| ORD ID | ord-6fae201f97de4032bc83c2c6c96c1ad5 |
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| Source note | uspto-grants-1999_03 |
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