HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazinecarboxaldehyde → 5,6-Dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazinecarboxaldehyde | HCID 12229 | — |
| Reactant | 1,3,4,5-tetrahydro-2H-1,5-benzodiazepine-2-thione | HCID 4381402 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 5,6-Dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine | HCID 21837004 | 37.3% |
Reaction Steps
A mixture of 2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-thione (0.8 g) and 0.80 g of N-formylhydrazine in 8 ml of n-butanol is stirred and refluxed for 18 hours and the solvent removed under vacuum. Ice water is added to the residual solid and the mixture filtered to give 0.312 g of a gray solid, m.p. 162°-165° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05889001 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-6ff6802a63344f899c519497e23ebb19 |
| Source note | uspto-grants-1999_03 |