HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 4-[(5-Fluoro-2-methylbenzoyl)amino]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 4-[(5-fluoro-2-methylbenzoyl)amino]benzoate | HCID 21837152 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4-[(5-Fluoro-2-methylbenzoyl)amino]benzoic acid | HCID 21837070 | 86.4% |
Reaction Steps
A mixture of 0.60 g of ethyl 4-[(5-fluoro-2-methylbenzoyl)amino]benzoate 0.60 ml of 10N NaOH, 25 ml of water and 50 ml of absolute ethyl alcohol is heated on a steam bath for 1 hour, cooled and acidified with acetic acid. The resulting solid is filtered and dried in vacuo at 60°-80° C. to give 0.47 g of the desired product as a solid, m.p. 272°-275° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05889001 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-3cc2be7f3a1e4867b9557cf499a9db5f |
| Source note | uspto-grants-1999_03 |