4-Chloro-2-phenyl-pyrimidine-5-carboxylic acid benzylamide → HCID 178418303, compound

HRID 1420100Notes

Reaction equation

HRID 1420100 reaction equation
[CH2:1]([NH:8][C:9]([C:11]1[C:12](Cl)=[N:13][C:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[N:15][CH:16]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[SH2:24].[Na]>>[CH2:1]([NH:8][C:9]([C:11]1[C:12]([SH:24])=[N:13][C:14]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[N:15][CH:16]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 539375004-Chloro-2-phenyl-pyrimidine-5-carboxylic acid benzylamideHCID 86586439Sodium hydrogen sulphide

Product 1

HCID 178418303HCID 178418303, compoundYield 16.2%

Procedure

Using the procedure from Preparation 34, 5.8 g (17.9 mol) of 4-chloro-2-phenyl-pyrimidine-5-carboxylic acid benzylamide was reacted with 5.1 g (72 mmol) of sodium hydrogen sulfide to give 3.75 g of the title compound, mp 189°-193° C.

Sources & evidence

ORD record
ord-0a3a9fb5d0054af2b2cf6a1e1d2762ef
Source dataset
uspto-grants-1999_03
Patent number
US05889034

Reaction notes

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