Iodine → HCID 23287878, compound

HRID 1420113Notes

Reaction equation

HRID 1420113 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH2:8][NH:9][C:10]([C:12]1[C:13]([SH:24])=[N:14][C:15]([N:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)=[N:16][CH:17]=1)=[O:11].II>>[N:18]1([C:15]2[N:14]=[C:13]3[S:24][N:9]([CH2:8][CH2:7][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=4)[C:10](=[O:11])[C:12]3=[CH:17][N:16]=2)[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 807IodineHCID 178418462HCID 178418462, compound

Product 1

HCID 23287878HCID 23287878, compoundYield 65.2%

Procedure

Using the procedure of Example 20, 33.0 g (96.2 mmol) of 4-mercapto-2-piperidin-1-yl-pyrimidine-5-carboxylic acid (2-pyridin-2-yl-ethyl)-amide were treated with 24.4 g (96.1 mmol) of iodine to give 21.4 g of the title compound after recrystallization from aqueous ethanol, mp 109°-110° C.

Sources & evidence

ORD record
ord-77e39ec142b24e05a30ac0806a5602e3
Source dataset
uspto-grants-1999_03
Patent number
US05889034

Reaction notes

Loading…