1,4-Dioxane hydrochloride → HCID 178465616, compound

Participants

Reaction Steps

To a solution of 2-(butyloxycarbonylamino)-6-(1-iminoethylamino)-4,4-dioxo-4-thiahexanoic acid tert-butyl ester hydrochloride (300 mg) in dioxane (15 ml) was added 4N HCl/dioxane (10 ml) and the mixture allowed to stand at room temperature for 24 hrs. The reaction mixture was then evaporated to dryness and the semi-solid residue treated with water (2 ml) and evaporated to give a colourless glass. The crude product was purified by flash chromatography on SiO2 using CH3CN:CH3CO2H:H2O (5:2:2) as the eluant to give 172.5 mg of the title compound.

Provenance & Evidence