Dichloromethane → HCID 54115575, compound

Participants

Reaction Steps

A mixture of 7.8 gm of 4-fluoro-2-nitroaniline, 8.57 gm of 3-bromo propionylchloride (added at a temperature of 0° C. over a period of 0.3 hours), 6.5 gm of diisopropylethylamine and 150 ml CH2Cl2 was kept for 48 hours at 20-25° C. Water (300 ml) was added and the mixture was extracted with CH2C2. The CH2Cl2 extract was collected, washed with water (2×20 ml) and desiccated wtih Na2SO4. The crude product (14.7 gm) obtained after removal of solvents was used without further purification. A sample of this crude material (14.79 gm) exhibited the following data. M+/z of 292.

Provenance & Evidence