HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 15859133, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | 1-(3-chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one | HCID 1810419 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 15859133 | HCID 15859133 | — |
Reaction Steps
A mixture of 5.0 gm of 1 -t-butoxycarbonyl piperazine, 6.26 gm of 1-(3-chloro propyl)-2,3-dihydro-1H-benzimidazol-2-one (available from Janssen) and 4.16 gm diisopropylethylamine in 150 ml ethanol was kept for 12 hours at 80° C. Upon cooling to ambient temperature, 100 ml water was added and the mixture is extracted with CHCl3. The CHCl3. The CHCl3 extract was collected, washed with 20 ml water and dried over Na2SO4. After removing solvents 10 gm of a yellowish oil was obtained which was used without further purification in Example 10.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05889010 |
| Source dataset | uspto-grants-1999_03 |
| ORD ID | ord-abf88763466842c2acfe3e79cc179d94 |
| Source note | uspto-grants-1999_03 |