Acetic Acid → HCID 53784335, compound

Participants

Reaction Steps

To a refluxing, stirred mixture of (4-fluoro-2-nitro-phenyl)-{3-[4-(4-fluorophenyl) piperazin-1-yl]-butyl}-amine (0.38 gm), 10 ml acetic acid are added small portions of Zn dust (excess) until a nearly colorless reaction mixture is obtained approx. 4 hours). Insolubles are removed by filtration, washed with acetic acid and the combined acetic acid layer concentrated to a black oil. This oily residue is dissolved in ethyl acetate (50 ml) and washed with 2×10 ml water and brine. The organic layer is collected, the sovent removed and the residue purified by flash chromatography (solid phase: SiO2 ; eluent: gradient starting with ethyl acetate followed by ethyl acetate/methanol 8:2). Obtained are 0.1 gm of 5-fluoro-1-{3-[4-(4-fluoro-phenyl)-piperazin-1-yl]-butyl}-2-1H-benzoimidazole. (M+/Z 384.47).

Provenance & Evidence