Hydrochloric Acid → HCID 70346867, compound

Participants

Reaction Steps

To a solution of (S)-[1-(hydroxymethyl)-2-(3-pyridinyl)ethyl]carbamic acid 1,1-dimethylethyl ester (1.27 g, 5.03 mmol) in 1,4-dioxan (3 ml) was added 1,4-dioxan saturated with HCl gas (10 ml) followed by a further portion of 1,4-dioxan (10 ml). After 2 h at room temperature the precipitated solid was collected by filtration, washed with 1,4-dioxan (5 ml) and ether then dried in vacuo to give the title compound (0.928 g) as a solid, nmr(δ,DMSO-d6) includes 3.11(bd,2H), 3.4-3.7(m,3H), 7.86(dd,1H), 8.1-8.3(bs,3H), 8.45(d,1H), 8.81(d,1H), 8.9(s,1H).

Provenance & Evidence