HCID 54478759, compound → HCID 54339633, compound

HRID 1420486Notes

Reaction equation

HRID 1420486 reaction equation
C([O:8][C:9](=[O:39])[C@H:10]([CH2:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=2[C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])=[CH:22][CH:21]=1)[NH:11][C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])C1C=CC=CC=1>[Pd].C(O)C>[C:12]([NH:11][C@H:10]([C:9]([OH:39])=[O:8])[CH2:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=2[C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])=[CH:22][CH:21]=1)([O:14][C:15]([CH3:17])([CH3:16])[CH3:18])=[O:13]

Participants

4

Reactant 1

HCID 54478759HCID 54478759, compound

Product 1

HCID 54339633HCID 54339633, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of N-Boc-para-(2'-t butoxycarbonylphenyl)phenylalanine-benzyl ester and 10% Palladium on charcoal (0.030 g) in ethanol 20 mL was hydrogenated at 35 psi for 23.5 hours. The reaction mixture was filtered through celite and evaporated to dryness to give the N-Boc-para-(2'-t butoxycarbonylphenyl)phenylalanine (0.175 g).

Workup

  1. filtrationThe reaction mixture was filtered through celite
  2. customevaporated to dryness

Sources & evidence

ORD record
ord-e4bc45d9f4764564b71c8a97cedec5eb
Source dataset
uspto-grants-2000_06
Patent number
US06071707

Reaction notes

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