m-Chloroperbenzoic acid → HCID 18781944, compound

Participants

Reaction Steps

A solution of 4-methylthio-1-(9-phenyl-2-oxononyl)azetidin-2-one (0.993 g, 2.98 mmol) in dry dichloromethane (90 ml) was cooled to -50° C. and mCPBA (0.95 g, 2.58 mmol) in dry dichloromethane (50 ml) was added dropwise over 30 minutes, then stirred for 90 minutes at room temperature. This was washed with dil Na2SO3, dil NaHCO3 and water (×2), dried (MgSO4)and evaporated to a solid (1.09 g). This was purified by flash chromatography on silica gel eluted with petroleum ether/ethyl acetate 1 ethanol to give 4-methylsulphinyl-1-(9-phenyl-2-oxononyl)azetidin-2-one (Example 5) as a white waxy solid (0.718 g, 69%).

Provenance & Evidence