Pyrrolidine → HCID 18781976, compound

Participants

Reaction Steps

N-[6-(4-Fluorophenyl)hexyl]-[4-(3-allyloxycarbonylpropyl)thio-2-oxo-azetidin-1-yl]-acetamide (1.4 g) was dissolved in dry dichloromethane (30 ml) and the resulting solution treated with pyrrolidine (0.3 g) and (tetrakistriphenylphosphino)palladium (0.2 g) at room temperature until TLC analysis showed absence of starting material. The mixture was washed with dilute HCl, brine, dried (MgSO4) and evaporated. The residue was purified by chromatography on silica gel (dichloromethane:methanol:acetic acid, 90:9:1) to give the title compound as an oil, 0.7 g, 52% yield.

Provenance & Evidence