HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1420576Generated: October 25, 2026
Toluene → 1-[N-(2-trifluoromethylphenyl)-N-cyclohexylcarbonyl-2-aminoethyl]-4-(2-methoxyphenyl)piperazine
https://huagongshe.com/reaction/1420576
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-(2-Chloroethyl)-4-(2-methoxyphenyl)piperazine | HCID 595673 | — |
| Reactant | N-[2-(trifluoromethyl)phenyl]cyclohexanecarboxamide | HCID 1367212 | — |
| Catalyst | Benzyl triethylammonium chloride | HCID 66133 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-[N-(2-trifluoromethylphenyl)-N-cyclohexylcarbonyl-2-aminoethyl]-4-(2-methoxyphenyl)piperazine | HCID 22458105 | 33.2% |
Reaction Steps
A mixture of N-(2-trifluoromethylphenyl)cyclohexanecarboxamide (0.2 g) (compd 26A), 1-(2-chloroethyl)-4-(2-methoxyphenyl)piperazine (0.37 g), 50% (w/w) NaOH (0.5 mL), TEBAC (0.16 g) and toluene (2 mL) was stirred at 80° C. for 3.5 h. An additional amount of compd 26A (0.2 g) was then added and after 6 h stirring at 80° C. The mixture was poured into H2O and extracted with CH2Cl2. The organic phase was dried on anhydrous Na2SO4, evaporated to dryness and the residue purified by flash chromatography (EtOAc-petroleum ether 3:7) giving 0.12 g (17%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06071920 |
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| Source dataset | uspto-grants-2000_06 |
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| ORD ID | ord-5908c911585d407183a131013bc9feb6 |
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| Source note | uspto-grants-2000_06 |
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