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Diisopropylethylamine → 1-phenyl-N-(2-nitrophenyl)cyclohexanecarboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 1-Phenylcyclohexanecarbonyl chloride | HCID 10353537 | — |
| 反応物 | HCID 22458203 | HCID 22458203 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 1-phenyl-N-(2-nitrophenyl)cyclohexanecarboxamide | HCID 18782311 | 91% |
反応手順
This compound was prepared following the procedure described for compound 39A in example 39, except that 1-phenylcyclohexanecarbonyl chloride (J. Am. Chem. Soc. 68, 2345-7 (1946)) was used in place of 1-methylcyclohexanecarbonyl chloride, toluene in place of CH2Cl2, DIPEA in place of triethylamine and reaction mixture was refluxed for 15 h. The crude was purified by flash chromatography (petroleum ether-EtOAc 98:2). Yield 91%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06071920 |
| 出典データセット | uspto-grants-2000_06 |
| ORD ID | ord-4b2e0c04a17c4d4389f9e9c5ea5374a0 |
| 出典メモ | uspto-grants-2000_06 |