HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → Methyl 3-Hydroxy-2-[(4-methoxybenzenesulfonyl)-(4-chloro-2-nitrobenzyl)amino]propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-Chloro-1-(chloromethyl)-2-nitrobenzene | HCID 598399 | — |
| Reactant | Methyl 3-hydroxy-2-(4-methoxybenzenesulfonylamino)propionate | HCID 11173760 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Methyl 3-Hydroxy-2-[(4-methoxybenzenesulfonyl)-(4-chloro-2-nitrobenzyl)amino]propionate | HCID 18612795 | — |
Reaction Steps
To a solution of 0.289 g (1 mmol) of methyl 3-hydroxy-2-(4-methoxybenzenesulfonylamino)propionate in 4 ml of N,N-dimethylformamide cooled in an ice bath was added 40 mg of NaH (60% in oil) (1 mmol). After the gas evolution ceased, 0.165 g (1.1 mmol) of sodium iodide was added, followed by the addition of 0.226 g (1.1 mmol) of 4-chloro-2-nitrobenzyl chloride in 1 ml of dimethylformamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06071903 |
| Source dataset | uspto-grants-2000_06 |
| ORD ID | ord-2e12885b14ce417090493920390c3419 |
| Source note | uspto-grants-2000_06 |