Sodium Hydroxide → HCID 18612898, compound

Participants

Reaction Steps

To a solution of 5.14 g (14.1 mmol) of methyl 2-[(2-aminobenzyl)-(4-methoxybenzenesulfonyl)amino]acetate in 50 ml of methanol-tetrahydrofuran (1:1) was added 2.86 ml of 10 N NaOH and the mixture refluxed for 2 hours. The solvent was removed under vacuum and the residue partitioned between water and ether. The water layer was separated and acidified with 2 N citric acid. The solid was filtered, washed with H2O and dried in a vacuum oven at room temperature to give 4.45 g (91%) of crystals, m.p. 145°-147° C. Anal. for C16H18N2O5S: Calc'd: C,54.9; H,5.2; N,8.0; Found: C,55.1; H,5.2; N,7.9.

Provenance & Evidence