反应详情

To a solution of 3.4 g of methyl 3-hydroxy-2-[(4-methoxybenzenesulfonyl)-(5-methyl-2-nitrobenzyl)-amino]propionate in 200 ml of ethanol-ethyl acetate (1:1) was added 0.34 g of 10% palladium on carbon (wet -50% H2O). The mixture was then shaken in a Parr hydrogenator under 35 psi of hydrogen for 2.5 hours. The mixture was filtered through diatomaceous earth and the filtrate concentrated under vacuum to give 2.86 a of a brown oil. Anal. for Cl19H4N2O6S: Calc'd: C,55.9; H,5.9; N,6.9: Found: C,55.6; H,5.9; N,6.4: Mass spectrum (ES) 409 (M+H).

1. filtrationThe mixture was filtered through diatomaceous earth
2. concentrationthe filtrate concentrated under vacuum
3. customto give 2.86 a of a brown oil