Sodium Hydroxide → HCID 18612994, compound

Participants

Reaction Steps

A mixture of 1.0 g (2.3 mmol) of methyl 4-(4-methoxybenzenesulfonyl)-1-(2-methoxyethyl)-2,3,4,5-tetrahydro-1H-[1,4]benzodiazepine-3-carboxylate and 3.0 ml of 1N NaOH in 10 ml of tetrahydrofuran was stirred at room temperature for 2 hours and the solvent removed. To the residue was added water and the mixture acidified with 1N HCl. The mixture was extracted with ethyl acetate and the extract was washed with brine and dried with Na2SO4. The solvent was removed and the residue triturated with ethyl acetate-hexane, cooled and filtered to give 0.65 g of white crystals, m.p. 164°-165° C.,; Mass spectrum (ES) 421.4 (M+H). Anal. for C20H24N2O6S: Calc'd: C,57.1; H,5.8; N,6.7; Found: C,57.3; H,5.7; N,6.4.

Provenance & Evidence