HRID1420619

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)C1CNc2ccccc2CN1S(=O)(=O)c1ccc(OC)cc1

HCID18612753

未命名化合物

HCID22605446

未命名化合物

PRODUCTS

生成物

结构：COC(=O)C1CN(C(=O)c2ccc(-n3ccc(C)n3)cc2Cl)c2ccccc2CN1S(=O)(=O)c1ccc(OC)cc1

HCID17926485

未命名化合物

PROCEDURE

实验过程

As described in Example 65, methyl 4-(4-methoxybenzenesulfonyl)-2,3,4,5-tetrahydro-1H-[1,4]benzodiazepine-3-carboxylate was reacted with 4-(3-methyl-1-pyrazolyl)-2-chlorobenzoyl chloride to give methyl 4-(4-methoxybenzenesulfonyl)-1-[2-chloro-4-(3-methyl-1-pyrazolyl)phenylcarbonyl]-2,3,4,5-tetrahydro-1H-[1,4]benzodiazepine-3-carboxylate as a white solid. Anal. for C29H27ClN4O6S: Calc'd: C, 58.3; H, 4.6; N, 9.4. Found: C,58.2; H, 4.9; N, 8.9.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fbd4622d3ef74a49bbaf7a64864ce9cb
来源数据集: uspto-grants-2000_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06071903
来源说明: uspto-grants-2000_06

反应 SMILES

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:12]2[CH2:18][C:17]3[CH:19]=[CH:20][CH:21]=[CH:22][C:16]=3[NH:15][CH2:14][CH:13]2[C:23]([O:25][CH3:26])=[O:24])(=[O:11])=[O:10])=[CH:5][CH:4]=1.[CH3:27][C:28]1[CH:32]=[CH:31][N:30]([C:33]2[CH:41]=[CH:40][C:36]([C:37](Cl)=[O:38])=[C:35]([Cl:42])[CH:34]=2)[N:29]=1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:12]2[CH2:18][C:17]3[CH:19]=[CH:20][CH:21]=[CH:22][C:16]=3[N:15]([C:37]([C:36]3[CH:40]=[CH:41][C:33]([N:30]4[CH:31]=[CH:32][C:28]([CH3:27])=[N:29]4)=[CH:34][C:35]=3[Cl:42])=[O:38])[CH2:14][CH:13]2[C:23]([O:25][CH3:26])=[O:24])(=[O:10])=[O:11])=[CH:5][CH:4]=1