Methyl iodide → HCID 18782400, compound

HRID 1420670Notes

Reaction equation

[ClH:1].[CH:2]1([N:14]2[CH2:30][CH2:29][C:17]3([N:21]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:20][NH:19][C:18]3=[O:28])[CH2:16][CH2:15]2)[C:12]2=[C:13]3[C:8](=[CH:9][CH:10]=[CH:11]2)[CH:7]=[CH:6][CH:5]=[C:4]3[CH2:3]1.[CH3:31]I>>[ClH:1].[CH:2]1([N:14]2[CH2:15][CH2:16][C:17]3([N:21]([C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH2:20][N:19]([CH3:31])[C:18]3=[O:28])[CH2:29][CH2:30]2)[C:12]2=[C:13]3[C:8](=[CH:9][CH:10]=[CH:11]2)[CH:7]=[CH:6][CH:5]=[C:4]3[CH2:3]1

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 18782381Ro65-6570 HCl

Product 1

HCID 18782400HCID 18782400, compound

Procedure

The title compound, light brown solid, m.p.>185° C. (dec.) and MS: m/e=398.3 (M+H+) was prepared in accordance with the general method of example 4 from (RS)-8-(acenaphthen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one hydrochloride (1:1) and methyl iodide.

Sources & evidence

ORD record: ord-3712a18b069746a8a786c18cedce26b9
Source dataset: uspto-grants-2000_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06071925

Reaction notes

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