Potassium Carbonate → HCID 18782783, compound

Participants

Reaction Conditions

Reaction Steps

Compound 3 (2.58 g, 0.0056 mol) was dissolved in dry DMF (80 mL), 4-(4-chlorophenyl)piperidin-4-ol (1.0 g, 0.0047 mol) and K2CO3 (0.57 g, 0.0056 mol) were added. The resulting mixture was stirred at 50-60° C for 12 h and at room temperature for 48 h. The reaction mixture was concentrated to dryness in vacuo and CH2Cl2 (100 mL) was added. The organic phase was washed with 5% NaHCO3 (aq) (100 mL), brine (50 mL), dried (MgSO4), filtered and the solvent evaporated in vacuo, to give 4.8 g of an oil. The residual oil was purified on a silica gel column (Eluent: ethyl acetate/n-heptane (1:1)). The product was acidified with 2M HCl(g) in diethylether, giving the title compound 1.6 g (75%). M.p. 194.5-195.5° C.

Provenance & Evidence