Water → HCID 178517755, compound

HRID 1420715Notes

Reaction equation

HRID 1420715 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:8])=[N:6][CH:7]=1.[Br:9]Br.O>C(O)(=O)C>[Br:9][C:4]1[C:5]([OH:8])=[N:6][CH:7]=[C:2]([Cl:1])[CH:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 24408BromineHCID 1785160645-chloropyridin-2-ol

Product 1

HCID 178517755HCID 178517755, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 5-chloro-2-hydroxypyridine (100 g) and bromine (40.1 mL) in acetic acid (400 mL) was stirred at r.t. for 1 h. The mixture was poured into 3 L of water and stirred for 30 min then filtered. The residual solid was washed with 2 L of cold water, air dried and then coevaporated with toluene three times and with benzene two times. The white solid (81 g) so obtained was used in the subsequent reaction.

Workup

  1. stirringstirred for 30 min
  2. filtrationthen filtered
  3. washThe residual solid was washed with 2 L of cold water, air
  4. customdried

Sources & evidence

ORD record
ord-43752b03d7184a0f9a3896a3f36c3a01
Source dataset
uspto-grants-2000_06
Patent number
US06071936

Reaction notes

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