Isopropylamine → HCID 70230534, compound

HRID 1420744Notes

Reaction equation

HRID 1420744 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)/[C:7](=[CH:11]\[C:12]1[CH:17]=[CH:16][C:15]([S:18]([CH3:21])(=[O:20])=[O:19])=[CH:14][CH:13]=1)/[C:6]([CH3:22])=[C:5]2[CH2:23][N:24]=[C:25]=[O:26].[CH:27]([NH2:30])([CH3:29])[CH3:28]>C1(C)C=CC=CC=1.CCCCCC>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)/[C:7](=[CH:11]\[C:12]1[CH:17]=[CH:16][C:15]([S:18]([CH3:21])(=[O:19])=[O:20])=[CH:14][CH:13]=1)/[C:6]([CH3:22])=[C:5]2[CH2:23][NH:24][C:25]([NH:30][CH:27]([CH3:29])[CH3:28])=[O:26]

Participants

5

Reactant 2

HCID 6363IsopropylamineHCID 86755448HCID 86755448, compound

Product 1

HCID 70230534HCID 70230534, compoundYield 75%

Reagents, catalysts & solvents 2

HCID 1140TolueneSolventHCID 8058HexaneSolvent

Procedure

To a solution of the isocyanate from Step 1 in toluene was added 1.2 equivalent of isopropylamine. The reaction mixture was kept under reflux for 1 h. After having been cooled to room temperature, the mixture was diluted with n-hexane to form a yellow precipitate, which was filtered off, and was recrystallized from CH2Cl2, to give the title compound as a yellow solid (75%), mp: 217° C.

Workup

  1. temperatureunder reflux for 1 h
  2. customto form a yellow precipitate, which
  3. filtrationwas filtered off
  4. customwas recrystallized from CH2Cl2

Sources & evidence

ORD record
ord-514dbbfc294148dcb5b8d04141276139
Source dataset
uspto-grants-2000_06
Patent number
US06071934

Reaction notes

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