Methylhydrazine → HCID 178481940, compound

HRID 1420765Notes

Reaction equation

HRID 1420765 reaction equation
[C:1]1(=O)[O:6][C:4](=[O:5])[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[CH3:12][NH:13][NH2:14]>C(O)(=O)C.O>[OH:6][C:1]1[C:2]2[C:3](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4](=[O:5])[N:13]([CH3:12])[N:14]=1

Participants

5

Reactant 2

HCID 6061MethylhydrazineHCID 6811Phthalic Anhydride

Product 1

HCID 178481940HCID 178481940, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

Phthalic anhydride (7.4 g) was dissolved in hot acetic acid (50 ml) and a solution of methylhydrazine (2.7 ml) in water (50 ml) was added. The mixture was heated under reflux for 15 minutes and left to cool overnight. The precipitate that formed was filtered off, washed with water and dried under reduced pressure at 65° C. to yield 1,2-dihydro-4-hydroxy-2-methyl-1-oxophthalazin (7.6 g) as a white solid. m.p. 243-244° C.

Workup

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 15 minutes
  3. waitleft
  4. temperatureto cool overnight
  5. customThe precipitate that formed
  6. filtrationwas filtered off
  7. washwashed with water
  8. customdried under reduced pressure at 65° C.

Sources & evidence

ORD record
ord-d15553d57ff64044a7df816ee8f6a5c2
Source dataset
uspto-grants-2000_06
Patent number
US06071938

Reaction notes

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