Ammonia → HCID 178433472, compound

HRID 1420766Notes

Reaction equation

HRID 1420766 reaction equation
[CH3:1][C:2]1[C:3]([OH:10])=[CH:4][C:5](=O)[O:6][C:7]=1[CH3:8].[NH3:11]>O1CCOCC1>[OH:6][C:5]1[CH:4]=[C:3]([OH:10])[C:2]([CH3:1])=[C:7]([CH3:8])[N:11]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 547129154-Hydroxy-5,6-dimethyl-2H-pyran-2-one

Product 1

HCID 178433472HCID 178433472, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

5,6-Dimethyl-4-hydroxy-2-oxo-2H-pyran (11.92 g) (see J.C.P.Perkin Trans. 1, 1980, 2272) was dissolved in 1,4-dioxane (80 ml), aqueous 35% ammonia solution (40 ml) was added and the mixture was heated under reflux for 90 minutes. The solution was left to cool overnight, the precipitate filtered off and dried under reduced pressure at 90° C. for 24 hours to yield 2,4-dihydroxy-5,6-dimethylpyridine (3.47 g) as a white solid.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 90 minutes
  3. waitThe solution was left
  4. temperatureto cool overnight
  5. filtrationthe precipitate filtered off
  6. customdried under reduced pressure at 90° C. for 24 hours

Sources & evidence

ORD record
ord-3ef072782c3b436880ba61eaa30b69ce
Source dataset
uspto-grants-2000_06
Patent number
US06071938

Reaction notes

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