7379-35-3 → HCID 11243907, compound

HRID 1420769Notes

Reaction equation

HRID 1420769 reaction equation
CO[C:3]1(OC)[CH2:7][CH2:6][CH2:5]O1.[Cl-].ClC1C=C[NH+]=CC=1.[NH2:18][C:19]1[C:23]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[O:30][CH3:31])=[CH:22][S:21][C:20]=1[C:32]([O:34][CH3:35])=[O:33]>O1CCOCC1>[CH3:31][O:30][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=1[C:23]1[C:19]([N:18]2[CH:3]=[CH:7][CH:6]=[CH:5]2)=[C:20]([C:32]([O:34][CH3:35])=[O:33])[S:21][CH:22]=1

Participants

5

Reactant 3

HCID 108772907379-35-3HCID 11311579HCID 11311579, compoundHCID 11788317dimethoxytetrahydrofurane

Product 1

HCID 11243907HCID 11243907, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

5.2 mmol of dimethoxytetrahydrofuran and 5.2 mmol of 4-chloropyridinium chloride in 100 ml of dioxane are stirred for 15 minutes at ambient temperature and then 5.2 mmol of the compound obtained in Step C are added. The reaction mixture is then heated at reflux of the solvent for 3 hours and subsequently filtered. After concentrating the filtrate under reduced pressure, the residue obtained is crystallised by trituration in ethyl ether, allowing the expected product to be isolated.

Workup

  1. temperatureThe reaction mixture is then heated
  2. temperatureat reflux of the solvent for 3 hours
  3. filtrationsubsequently filtered
  4. concentrationAfter concentrating the filtrate under reduced pressure
  5. customthe residue obtained
  6. customis crystallised by trituration in ethyl ether
  7. customto be isolated

Sources & evidence

ORD record
ord-26cb5e0cfa7247b680d4ed77986e50ee
Source dataset
uspto-grants-2000_06
Patent number
US06071945

Reaction notes

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