Bromine → HCID 9906877, compound

HRID 1420770Notes

Reaction equation

HRID 1420770 reaction equation
[Br:1]Br.[CH3:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:21]3[N:20]4[C:16](=[CH:17][CH:18]=[CH:19]4)[C:15](=[O:22])[C:14]=3[S:13][CH:12]=2)=[CH:7][CH:6]=1>C(Cl)(Cl)Cl>[Br:1][C:18]1[CH:17]=[C:16]2[N:20]([C:21]3[C:11]([C:8]4[CH:7]=[CH:6][C:5]([O:4][CH3:3])=[CH:10][CH:9]=4)=[CH:12][S:13][C:14]=3[C:15]2=[O:22])[CH:19]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 385455NSC676693

Product 1

HCID 9906877HCID 9906877, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

2.1 mmol of bromine are added to a solution of 1.8 mmol of 3-(4-methoxyphenyl)-8H-thieno[2.3-b]pyrrolizin-8-one in 50 ml of chloroform. After two hours' stirring the solvent is evaporated off under reduced pressure. Chromatography on silica gel (dichloromethane) allows the expected product to be isolated.

Workup

  1. customis evaporated off under reduced pressure
  2. customto be isolated

Sources & evidence

ORD record
ord-bc7d2541b3bb40c9b6339911f59b64cd
Source dataset
uspto-grants-2000_06
Patent number
US06071945

Reaction notes

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