Ammonium → 4-[(1-Azetidin-3-ylpiperidin-4-yl)carbonyl]morpholine

HRID 142080Notes

Reaction equation

HRID 142080 reaction equation
[CH3:36][CH2:37][OH:38].[CH:32]([O-:33])=[O:34].[NH4+:35].[OH-:39].[OH-:41].[Pd+2:40].[c:1]1([CH:2]([c:3]2[cH:4][cH:5][cH:6][cH:7][cH:26]2)[N:8]2[CH2:9][CH:10]([N:12]3[CH2:13][CH2:14][CH:15]([C:18](=[O:19])[N:20]4[CH2:21][CH2:22][O:23][CH2:24][CH2:25]4)[CH2:16][CH2:17]3)[CH2:11]2)[cH:27][cH:28][cH:29][cH:30][cH:31]1>>[NH:8]1[CH2:9][CH:10]([N:12]2[CH2:13][CH2:14][CH:15]([C:18](=[O:19])[N:20]3[CH2:21][CH2:22][O:23][CH2:24][CH2:25]3)[CH2:16][CH2:17]2)[CH2:11]1

Participants

7

Reactant 6

HCID 223AmmoniumHCID 283FormateHCID 702EthanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 236589584-({1-[1-(Diphenylmethyl)azetidin-3-yl]piperidin-4-yl}carbonyl)morpholine

Product 1

HCID 236589574-[(1-Azetidin-3-ylpiperidin-4-yl)carbonyl]morpholine

Sources & evidence

ORD record
ord-cadba9dadfd44ba9846f257edf06a1e2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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