HuagongsheHuagongshe Chemistry Print Report · For research reference only
Picolyl chloride hydrochloride → 4-(3-Acetoxy-4-methylanilino)-6-methoxy-7-(2-pyridylmethoxy)quinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Picolyl chloride hydrochloride | HCID 23392 | — |
| Reactant | 4-(3-Acetoxy-4-methylanilino)-7-hydroxy-6-methoxyquinazoline hydrochloride | HCID 135671180 | — |
| Product | 4-(3-Acetoxy-4-methylanilino)-6-methoxy-7-(2-pyridylmethoxy)quinazoline | HCID 22624927 | 40% |
Reaction Steps
Using an analogous procedure to that described for the starting material in Example 1, 4-(3-acetoxy-4-methylanilino)-7-hydroxy-6-methoxyquinazoline hydrochloride (376 mg) was reacted with 2-(chloromethyl)pyridine hydrochloride (328 mg) to give 4-(3-acetoxy-4-methylanilino)-6-methoxy-7-(2-pyridylmethoxy)quinazoline (170 mg, 40%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06071921 |
| Source dataset | uspto-grants-2000_06 |
| ORD ID | ord-5ad8dc929ce84ce78ed3717c7a763266 |
| Source note | uspto-grants-2000_06 |